Genetically engineered senescence-resistant human mesenchymal progenitor cells promote spinal cord injury repair.

ABSTRACT: Spinal cord injury (SCI) is a devastating condition affecting the central nervous system, often leading to persistent neurological dysfunction. While mesenchymal progenitor cells (MPCs) hold considerable promise for treating various disorders, their application in SCI repair remains hampered by challenges such as poor efficacy and safety concerns. In this study, we developed genetically engineered human MPCs with enhanced resistance to senescence and stress-termed senescence- and stress-resistant cells (SRCs)-and systematically evaluated their therapeutic potential and mechanisms in SCI repair. Intramedullary implantation of SRCs improved functional recovery after SCI. Mechanistically, SRCs exerted therapeutic effects through a dual approach: by mitigating neuronal and axonal loss while st

SUBMITTER: Ning T 

PROVIDER: S-EPMC12909257 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature