Effect of telomere length and related gene polymorphism in signaling pathway on semen quality.

ABSTRACT: This study investigates sperm telomere length (STL), gene polymorphisms in telomere-related pathway genes, and semen quality, were detected to evaluate their potential as a biomarkers of semen quality. Associationally, it explores between gene polymorphisms and STL, and semen quality. A total of 1,349 male volunteers from the Pu-yang Reproductive Medicine Center were selected as research subjects. Computer-aided sperm analysis analysis was employed to assess semen parameters. Real-time fluorescence quantitative PCR was utilized to measure STL, while polymerase chain reaction was used to detect gene polymorphisms. The correlation between STL, related gene polymorphisms, and semen parameters was subsequently analyzed. Among the 1,349 subjects, the proportions of semen volume, total sperm cou

SUBMITTER: Jia X 

PROVIDER: S-EPMC12909296 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature