The Relationship Between Esophageal Motility Disorders and Varicella Zoster Virus: A Study Using Salivary DNA.

ABSTRACT:

Background

The causes of most esophageal motility disorders (EMDs) remain unknown. Recent reports have suggested a potential association between the EMD achalasia and varicella zoster virus (VZV) reactivation. This study aimed to investigate the relationship between various EMDs and VZV infection.

Methods

This was cross-sectional study. The participants in this study underwent high-resolution manometry (HRM) at Chiba University Hospital between 2022 and 2024. Saliva and blood samples were collected from all patients. The presence of VZV DNA in the saliva was determined using nested polymerase chain reaction (PCR) and electrophoresis. VZV-immunoglobulin M and immunoglobulin G antibody titers were measured in the blood samples. Based on the HRM results, the patients were divid

SUBMITTER: Takahashi S 

PROVIDER: S-EPMC12909326 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature