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Patterns and persistence of use, effectiveness, safety, clinical inertia, and adherence related to Levothyroxine treatment with real-world evidence. An observational, longitudinal and retrospective study.


ABSTRACT:

SUBMITTER: Valladales-Restrepo LF 

PROVIDER: S-EPMC12909374 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature

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Patterns and persistence of use, effectiveness, safety, clinical inertia, and adherence related to Levothyroxine treatment with real-world evidence. An observational, longitudinal and retrospective study.

Valladales-Restrepo Luis Fernando LF   Londoño-Cano Diego Andrés DA   Muñoz-Velez Carlos Mauricio CM   Soto-Romero Lian Manuela LM   Tafur-Ramirez Marlon Eleazart ME   Rojas-Varón Maria José MJ   Machado-Alba Jorge Enrique JE  

Endocrine 20260216 1


PURPOSE: Over- and undertreatment of chronic diseases are common. In this context, real-world data on the use of levothyroxine are limited. The aim was to determine the patterns of use, persistence, effectiveness, safety, clinical inertia, and adherence related to levothyroxine treatment in a group of patients with thyroid disease in Colombia. MATERIALS AND METHODS: This was an observational study of patients treated with levothyroxine. Clinical records were reviewed, and the minimum patient fol  ...[more]

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