Association of remnant cholesterol with cognitive impairment: a cross-sectional study.

ABSTRACT:

Background

Although dyslipidemia has been implicated in the development of cognitive impairment, the association between remnant cholesterol (RC) and cognitive outcomes remains incompletely understood.

Methods

We conducted a cross-sectional study using data from 1,136 participants at Liuyang Jili Hospital from 2022. RC was calculated as total cholesterol minus low-density and high-density lipoprotein cholesterol, and cognitive function was assessed using the Mini-Mental State Examination. Restricted cubic spline and multivariable logistic regression models were used to evaluate associations between RC and cognitive impairment, with subgroup, and sensitivity analyses. Machine learning models with SHapley additive explanation (SHAP) values were applied to assess variable impor

SUBMITTER: Bai W 

PROVIDER: S-EPMC12909580 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature