Effect of Early Administration of Anti-MRSA Drugs for Febrile Neutropenia in Allogeneic Hematopoietic Cell Transplantation.

ABSTRACT:

Background

In febrile neutropenia (FN), the empirical use of anti-methicillin-resistant Staphylococcus aureus (MRSA) drugs is recommended, particularly when mucosal damage occurs during fluoroquinolone antibiotic administration. Therefore, the early use of anti-MRSA drugs may be recommended in many cases of FN after allogeneic hematopoietic cell transplantation (allo-HCT), but the evidence regarding their efficacy is limited.

Objectives

To assess the impact of early administration of anti-MRSA drugs on the resolution of fever in patients undergoing allo-HCT.

Methods

We retrospectively analyzed 186 allo-HCT patients. Patients receiving anti-MRSA drugs within 3 days of fever onset formed the early-decision group; those treated on or after Day 4 or untreated forme

SUBMITTER: Akaogi A 

PROVIDER: S-EPMC12910238 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature