3,5-Dicaffeoylquinic Acid Delayed Aging and Promoted Oxidative Stress Tolerance via Activation of the SKN-1/Nrf2 Signaling Pathway.

ABSTRACT: 3,5-Dicaffeoylquinic acid (3,5-diCQA), as a plant-derived polyphenol, exhibits multiple bioactivities, including anti-inflammation, antioxidation, and anti-diabetes. A previous report demonstrated that 3,5-diCQA increased the lifespan and promoted the healthspan in Caenorhabditis elegans. Nevertheless, the molecular mechanisms underlying the function of 3,5-diCQA remain to be further determined. In this study, 3,5-diCQA promoted the transfer of SKN-1 to nucleus and upregulated the expressions of its downstream genes. Moreover, 3,5-diCQA enhanced oxidative stress tolerance and decreased ROS level in a skn-1-dependent manner. Consistently, 3,5-diCQA remarkably reduced the ROS level and delayed senescence of MRC-5 cells by activating Nrf2. Notably, molecular docking results reve

SUBMITTER: Li R 

PROVIDER: S-EPMC12910240 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature