The clinical utility of nasal MRSA PCR as an antimicrobial stewardship tool to guide MRSA bacteraemia therapy in paediatrics: a retrospective study at a tertiary care centre.

ABSTRACT:

Objectives

Vancomycin is the main therapeutic choice for paediatric methicillin-resistant Staphylococcus aureus (MRSA) infections. However, its use is associated with many clinical challenges. This study aimed to investigate the use of MRSA polymerase chain reaction (PCR) as an antimicrobial stewardship tool to enhance therapeutic decision-making in paediatric MRSA bacteraemia.

Methods

This retrospective cohort study was conducted at a tertiary healthcare centre from January 2021 to January 2024. It included paediatric patients who were screened for MRSA nasal colonization via PCR and had a blood culture obtained within 7 days of the MRSA PCR collection date. Clinical characteristics were compared between the positive and negative PCR groups. Positive and negative pre

SUBMITTER: Alrashed F 

PROVIDER: S-EPMC12910373 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature