PyTEA-O: a Python implementation of Two-Entropies Analysis for protein sequence variation analysis.

ABSTRACT:

Motivation

Protein sequence variation analysis is a topic of broad interest in drug discovery and protein engineering to support modulation of protein function for diverse biotechnological and therapeutic applications. To assist in the analysis of multiple sequence alignments (MSAs) and identify residues that account for protein function specificity, computational tools have been developed. Yet, existing programs often omit consideration of amino acid properties, flexibility beyond fixed webserver interfaces, accessible source code, or compatibility with small MSAs.

Results

To address these limitations, we present PyTEA-O, a Python implementation of Two-Entropies Analysis that has been developed to be easy to use for the analysis of protein sequence variation. To help users

SUBMITTER: Kuin RCM 

PROVIDER: S-EPMC12910380 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature