Persistent Severe Acute Kidney Injury Among Critically Ill Patients: Outcomes and Predictive Markers-A Single-Center Retrospective Cohort Study.

ABSTRACT:

Background

Persistent severe acute kidney injury (PS-AKI)-recently standardized as Kidney Disease: Improving Global Outcomes (KDIGO) Stage 3 persisting ≥ 72 h, or renal replacement therapy/death after Stage 3 diagnosis-has emerged as a trajectory-based phenotype complementing conventional KDIGO staging. Evidence in contemporary intensive care unit (ICU) cohorts remains limited.

Methods

We retrospectively studied adults admitted to a tertiary ICU (January 2024-June 2025). Acute kidney injury (AKI) was staged per KDIGO 2012, with trajectories classified as Stage 1 AKI, transient AKI (Stage 2-3 resolving within 48 h), persistent mild-moderate AKI, or PS-AKI. The primary outcome was in-hospital mortality; secondary outcomes included renal recovery. Predictors of PS-AKI were expl

SUBMITTER: Nguyen TP 

PROVIDER: S-EPMC12910387 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature