Genomic Epidemiology of West Nile Virus in Paris.

ABSTRACT:

Importance

West Nile virus (WNV), a mosquito-borne orthoflavivirus, represents an increasing public health threat in Europe. In July 2025, WNV lineage 2 (WNV-L2) was associated with the first autochthonous cases ever detected in the metropolitan area around Paris, France; understanding the dispersal dynamics and geographic origin of these emergence events is critical for public health preparedness.

Objectives

To characterize the spatial and temporal dynamics of WNV circulation in France from 2022 to 2025 and to determine the origin of the virus lineages responsible for the 2025 emergence in the Paris metropolitan area.

Design, setting, and participants

This study was a genomic epidemiology assessment combining human, veterinary, and entomological monitoring, with vira

SUBMITTER: Klitting R 

PROVIDER: S-EPMC12910402 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature