Novel Bioactive Multifunctional Polyphenols: A Chemo-Enzymatic Approach.

ABSTRACT: Stilbenes, such as resveratrol, possess numerous biological activities desirable in various industrial sectors (e.g., pharmaceutical, nutraceutical, and cosmetic). However, these activities are counteracted by their low bioavailability. In order to achieve an optimal hydrophylic/lipophilic balance (HLB) and thus maximize bioavailability, alkyl glucoside dimers of resveratrol (i.e., C2 to C12 alkyl oxystilbenin diglucosides (C8-O4' linkage) and δ-Viniferin diglucoside (C3-C8' linkage)) were synthesized from piceid-a β-glucoside of resveratrol-in one or two steps using a silver acetate-mediated oxidative coupling in various alcoholic solvents as the key step. δ-Viniferin diglucoside was functionalized by lauric acid using an enzyme-mediated esterification. HLB values, determined from Log P (

SUBMITTER: Flourat AL 

PROVIDER: S-EPMC12910418 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature