Hydrogel Microneedle Array-Based Transdermal Dressing System for Multiplexed Assessment and Intelligent Therapy of Chronic Wounds.

ABSTRACT: Topical chronic wound dressings offer personalized management but have limited efficacy in sensing and delivering therapeutics due to their reliance on the wound surface. Herein, a theranostic hydrogel-forming microneedles (HFMNs) dressing system is developed that penetrates the epidermis to continuously sample dermal wound interstitial fluid (ISF), providing high-fidelity diagnostics and active therapy. The dressing is fabricated from a polyvinyl alcohol/chitosan hydrogel incorporating MXene for intrinsic antibacterial and pro-healing properties. Central to the platform's design is a laser-scribed phase separation process that converts a poly(3,4-ethylenedioxythiophene): polystyrene sulfate/graphene oxide coating into highly conductive (384 S/m) and water-stable electrodes directly on the

SUBMITTER: Sharifuzzaman M 

PROVIDER: S-EPMC12910427 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature