Microwave-assisted N,S doped carbon quantum dots as fluorescent nanoprobes for vibegron determination: face-centered design optimization, validation, and green chemistry assessment.

ABSTRACT: A novel, sensitive, and environmentally sustainable spectrofluorimetric method was developed for vibegron quantification in pharmaceutical formulations and biological matrices using nitrogen and sulfur co-doped carbon quantum dots (N,S CQDs) as fluorescent nanoprobes. The N,S-CQDs were synthesized via rapid microwave-assisted green chemistry and comprehensively characterized through transmission electron microscopy, dynamic light scattering, Fourier-transform infrared spectroscopy, ultraviolet-visible absorption spectroscopy, and fluorescence spectroscopy, revealing optimal excitation and emission wavelengths at 344 nm and 418 nm, respectively. Mechanistic investigation demonstrated that vibegron induced concentration-dependent fluorescence quenching through static complex formation

SUBMITTER: Al Shmrany H 

PROVIDER: S-EPMC12910438 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature