Impact of chronic endometritis on assisted reproductive technology outcomes: a propensity score inverse probability weighting cohort study.

ABSTRACT:

Background

Chronic endometritis (CE), characterized by CD138⁺ plasma cell infiltration, has been proposed to impair reproductive outcomes in assisted reproductive technology (ART). However, current evidence remains inconsistent, and diagnostic criteria vary widely. This study aimed to evaluate whether CE diagnosis and antibiotic treatment influence clinical pregnancy, live birth, and miscarriage outcomes following in vitro fertilization with fresh embryo transfer (IVF-ET) and frozen embryo transfer (FET).

Methods

We retrospectively analyzed 3,041 embryo transfer cycles (1,507 IVF-ET; 1,534 FET) from 1,401 infertile women treated at the Reproductive Medicine Center of Liuzhou Hospital, Guangzhou Women and Children's Medical Center (2008-2023). Chronic endome

SUBMITTER: Huang W 

PROVIDER: S-EPMC12910471 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature