Association of Sleep Duration With Intracranial Atherosclerosis and Cerebral Small Vessel Disease: A Mediation by Metabolic Factors.

ABSTRACT:

Aims

This study aimed to explore the relationship between sleep duration and intracranial atherosclerosis and cerebral small vessel disease (CSVD), and pinpoint the potential mediating factors.

Methods

Data were derived from the cross-sectional baseline survey of the PRECISE (Poly-vascular Evaluation for Cognitive Impairment and Vascular Events) study. Participants were divided into short sleep (< 7 h), normal sleep (7-9 h), and long sleep (> 9 h) groups. The associations of sleep duration with intracranial atherosclerotic plaque, intracranial atherosclerotic burden, total CSVD score, and CSVD imaging markers were evaluated.

Results

We enrolled 3038 participants (53.5% women; mean age: 61.2 ± 6.7 years). A long sleep duration was correlated with a higher risk of intra

SUBMITTER: Chen H 

PROVIDER: S-EPMC12910520 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature