Leonurine alleviates lung ischemia-reperfusion injury through suppression of ferroptosis via RORα in male mice.

ABSTRACT: Lung ischemia-reperfusion injury (LIRI) is a complex pathological condition that significantly impairs clinical outcomes following lung transplantation and thoracic surgery. Leonurine (LEO), an alkaloid derived from Leonurus japonicus, which has known anti-inflammatory and antioxidant properties, has shown therapeutic potential in various oxidative stress-related diseases. However, the effects of LEO on LIRI and its underlying mechanisms remain unclear. In the present study, a murine model of LIRI was established using wild-type mice. LEO treatment significantly improved lung histopathology, reduced oxidative stress, decreased pulmonary edema, and enhanced survival. Bioinformatics analyses - including volcano plot, KEGG enrichment, and GSEA - identified ferroptosis as a key regulatory path

SUBMITTER: Chen W 

PROVIDER: S-EPMC12910573 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature