Body Mass Index and Vaccine-induced Immune Responses in Children Living With HIV.

ABSTRACT:

Background

Children living with HIV are experiencing rising rates of obesity, driven by both the side effects of antiretroviral therapy and the increasingly obesogenic environments. Obesity and HIV are both known to cause immune dysregulation, which may have a combined negative effect on vaccine-induced immune response in this vulnerable population. This study aimed to determine whether body mass index z-score (BMIz) is associated with vaccine-induced antibody concentrations in children living with HIV.

Methods

This study used data from clinical trials for 3 separate vaccines (hepatitis A, hepatitis B and pneumococcal [conjugate plus polysaccharide]) administered to children living with HIV. Enrollment was between September 1999 and March 2003 in the United States. Adjusted

SUBMITTER: Massa JD 

PROVIDER: S-EPMC12910707 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature