Electrochemical Activation of α-Carbonyl Alkoxyamines for Direct Nucleophilic Substitution.

ABSTRACT: The reactivity and synthetic utility of TEMPO-derived alkoxyamines as functional handles remains insufficiently explored. This report interrogates the factors governing the stereospecific substitution of electroactivated TEMPO-derived α-carbonyl alkoxyamines. Concurrent with direct electrolysis, electroanalytical studies and theoretical calculations provided a complementary platform by which one could predict the efficacy for substrates to undergo desired substitution using benzoic acid or N-sulfonyl carbamate nucleophiles.

SUBMITTER: Putziger J 

PROVIDER: S-EPMC12910718 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature