Potential oncogene VPS72 in hepatocellular carcinoma: prognostic and immune infiltration implications.

ABSTRACT:

Background

VPS72, primarily located in the nucleus, may play a role in hepatocellular carcinoma (HCC) progression. More research is required to assess if VPS72 mRNA or protein levels, along with clinical parameters, can diagnose or predict HCC and affect its progression through immune cell infiltration regulation.

Methods

This study explored VPS72 mRNA and protein levels in HCC using bioinformatics and clinical samples, examining their relationship with clinical factors and immune cell infiltration.

Results

VPS72 levels were higher in HCC patients and linked to histologic grade, clinical stage, and T stage. Elevated mRNA and protein levels of VPS72 were associated with preoperative alpha-fetoprotein (AFP) levels and tumor thrombus in HBV-related HCC, while genetic cha

SUBMITTER: Huang M 

PROVIDER: S-EPMC12910789 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature