The discordance of remnant cholesterol and low-density lipoprotein cholesterol as a predictor of diabetes, diabetic microvascular diseases, and cardiovascular disease.

ABSTRACT:

Background

The impact of discordance between remnant cholesterol (RC) and low-density lipoprotein cholesterol (LDL-c) on diabetes, diabetic kidney disease (DKD), diabetic retinopathy (DR) and cardiovascular disease (CVD) remains unclear. This study aims to explore the association between the discordance and these outcomes, using data from the National Health and Nutrition Examination Survey (NHANES) 1999.1-2020.3 and Clinical Medical College & Affiliated Hospital of Chengdu University.

Methods

We prespecified a ± 15 percentile-point cutoff for discordance between RC and LDL-c, defined as RC percentile minus LDL-c percentile. Using this rule, 11,826 NHANES participants (cohort 1) and 306 participants from the Clinical Medical College & Affiliated Hospital of Chengdu Universit

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12910847 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature