Effects of varying inhaled oxygen concentrations on lung function in older adult patients undergoing laparoscopic gastrointestinal surgery under general anesthesia: protocol of a prospective multicenter clinical study in China.

ABSTRACT:

Background

Postoperative pulmonary complications (PPCs) are severe and are of particular concern in older adult patients undergoing laparoscopic gastrointestinal surgery. Both 40% and 80% fraction of inspired oxygen (FiO₂) are commonly used for anesthesia. Presently, whether 40% FiO₂ can increase the oxygenation index of patients 48 h postoperatively and reduce PPCs remains controversial. Moreover, no clear consensus exists for older adult patients. Therefore, this study aims to compare the effects of low FiO₂ (40%) and high FiO₂ (80%) levels on postoperative pulmonary function in older adult study participants undergoing laparoscopic gastrointestinal surgery.

Methods

This multicenter, prospective, parallel-cohort, randomized contr

SUBMITTER: Zhang T 

PROVIDER: S-EPMC12910851 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature