MiR-92a as a potential biomarker and therapeutic target in heart failure: evidence from human and mouse studies.

ABSTRACT:

Background

This research investigated the expression of microRNA-92a (miR-92a) in chronic heart failure (CHF) patients and assessed its regulatory mechanism using a transverse aortic constriction (TAC) mouse model.

Methods

Thirty patients with CHF (NYHA class II-IV) and 30 age and sex-matched healthy controls were enrolled from January 2021 to April 2022. Plasma levels of miR-92a were analyzed by quantitative reverse transcription polymerase chain reaction (qRT-PCR). In addition, we utilized the TAC heart failure mouse model (n = 12) to evaluate the change in cardiac function following adeno-associated virus (AAV) mediated inhibition or overexpression of miR-92a. The following echocardiographic variables were evaluated: ejection fraction (EF), fractional shortening (FS), lef

SUBMITTER: Zhu L 

PROVIDER: S-EPMC12910911 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature