BTLA-mediated regulation of neuroimmune responses enhances recovery after intracerebral hemorrhage.

ABSTRACT:

Background

Modulating harmful neuroimmune responses is a promising therapeutic approach for hemorrhagic stroke, a condition that still lacks effective treatment. The immune checkpoint B and T Lymphocyte Attenuator (BTLA) helps suppress immune activation; however, its role in intracerebral hemorrhage (ICH) remains unclear. This study explores whether a BTLA-activating antibody can reduce neuroinflammation, mitigate brain injury, improve recovery after ICH, and elucidate the underlying mechanisms.

Methods

An ICH model was generated in male C57BL/6 mice by stereotactic injection of collagenase VII-S into the left striatum. The mice received intraperitoneal administration of an agonistic anti-BTLA antibody to serve as a BTLA agonist. Therapeutic effects were evaluated using a mu

SUBMITTER: Wu Y 

PROVIDER: S-EPMC12910923 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature