CT-based radiomics nomogram for preoperative prediction of Ki-67 in lung neuroendocrine neoplasms: a multicenter study.

ABSTRACT:

Objective

Lung neuroendocrine neoplasms (L-NENs) are increasingly recognized, yet reliable preoperative assessment of the Ki-67 proliferation index remains invasive and subject to sampling variability. We aimed to develop and validate a clinical-radiomics nomogram that uses routine chest CT to estimate Ki-67 status in patients with L-NENs.

Methods

In this retrospective multicenter study, 199 patients with histologically confirmed L-NENs from four hospitals between January 2014 and April 2024 were enrolled, all of whom underwent preoperative dual-phase contrast-enhanced CT. Following manual 3D tumor segmentation, a total of 1,874 radiomics features were extracted from fused non-contrast and arterial/venous phase images. Feature selection was performed using Pearson correlatio

SUBMITTER: Pan X 

PROVIDER: S-EPMC12910936 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature