Shuxuening injection improves ventricular remodeling after myocardial infarction by indirectly promoting macrophage-mediated angiogenesis and lymphangiogenesis.

ABSTRACT:

Background

Macrophage-mediated angiogenesis and lymphangiogenesis after myocardial infarction (MI) are essential for restoring cardiac perfusion and lymphatic drainage, thereby limiting cardiac tissue ischemia, edema, and fibrosis. Shuxuening injection (SXNI) is commonly used in the treatment of cardiovascular diseases in clinical practice, but its mechanism of action in mitigating cardiac remodeling after MI is still unclear.

Objective

This study aimed to investigate the effect of SXNI on ventricular remodeling after MI and to clarify its mechanism of action.

Methods

SXNI were administered at doses of 1.05 (low-dose), 2.1 (clinical equivalent-dose), and 4.2 (high-dose) mL/kg/day over a 4-week period by using a rat MI model. Pharmacodynamic assessments encompassed car

SUBMITTER: Yang L 

PROVIDER: S-EPMC12910987 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature