Imaging brain class I histone deacetylase changes in the Lewy body dementias and Parkinson's disease.

ABSTRACT:

Background

Histone deacetylases (HDACs) are epigenetic molecules responsible for regulation of gene transcription. Dysregulation of HDACs has been linked to neurodegenerative disease. Here, we used the class I HDAC PET radioligand [¹¹C]Martinostat to quantify and map changes in the distribution of these molecules in the brain in dementia with Lewy bodies (DLB) and Parkinson's disease (PD). In this exploratory cross-sectional study, we acquired brain PET-MR with [¹¹C]Martinostat in 14 DLB (median age 70 years (IQR 14), 21% female), 10 PD (median age 70 (8), 20% female) including four with cognitive impairment and six without, and 17 healthy control (HC) participants (median age 62 (14), 47% female). [¹¹C]Martinostat uptake was compared amongst groups

SUBMITTER: Goodheart AE 

PROVIDER: S-EPMC12911031 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature