Humidity impacts volatile anesthetic and heat responses of malignant hyperthermia susceptible mice.

ABSTRACT:

Background

Malignant Hyperthermia (MH) is characterized by life-threatening whole-body hyperthermic reactions triggered by volatile anesthetics in susceptible individuals. MH susceptibility (MHS) and exertional heat stroke (EHS) are linked to mutations in the type I ryanodine receptor (RYR1). However, the discordance between the estimated prevalence of RYR1 MHS mutations in the general population (1:625-1,075) and the occurrence of MH episodes during anesthesia (1:100,000) suggests additional factors beyond genetics.

Methods

Using an established MHS mouse model (Y524S or YS mice), 10-12-week-old WT and YS mice were exercised on a treadmill (20° incline, 15 m/min, 60 min) and/or exposed to heat (15 min at 37℃) or 2% isoflurane either in a low or high humid environment. A seco

SUBMITTER: He M 

PROVIDER: S-EPMC12911050 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature