Impact of ovarian stimulation duration in GnRH antagonist protocols on the cumulative ongoing pregnancy rate in women with normal ovarian reserve: a cohort study.

ABSTRACT:

Background

The optimal duration of ovarian stimulation in GnRH antagonist protocols remains insufficiently explored, despite its potential impact on oocyte quality, embryo development, and endometrial receptivity. Identifying an optimal stimulation window may improve success rates in assisted reproductive technologies (ART) while minimizing unnecessary hormonal exposure. The aim of the study was to evaluate if the duration of ovarian stimulation in GnRH antagonist IVF/ICSI protocols influence cumulative ongoing pregnancy rates (COPR).

Methods

This retrospective single-centre study analyzed 1456 IVF/ICSI cycles conducted between 2019 and 2023 in women with normal ovarian reserve using an antagonist protocol. Stimulation duration was classified into three categories: ≤ 8 days,

SUBMITTER: Cohen Aloro L 

PROVIDER: S-EPMC12911056 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature