Global research landscape of inborn errors of immunity: a bibliometric analysis (1991-2025).

ABSTRACT:

Background

Inborn errors of immunity (IEI), though individually rare, collectively represent a significant disease burden. From 1980 to 2024, classified IEI disorders expanded from dozens to 559 entities, reflecting advances ranging from immunoglobulin replacement to gene therapy.

Methods

This bibliometric analysis-a comprehensive mapping of the global IEI landscape-analyzed 7,455 publications (1991-2025) from Web of Science Core Collection using Bibliometrix, VOSviewer, and CiteSpace.

Results

Key findings: (1) Annual publication growth: 10.27% (H-index = 173); (2) US dominance: 36.3% publications, 115,221 citations, and TLS = 105,825; (3) Research priorities: Immunodeficiency mechanisms, clinical diagnostics, and key diseases (SCID, CVID, APDS); (4) Therapeutic front

SUBMITTER: Wu Q 

PROVIDER: S-EPMC12911067 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature