Deprescribing antihypertensive medications in older people: a systematic review and a meta-analysis.

ABSTRACT:

Introduction

Hypertension is highly prevalent among older people, and the balance of benefit and harm of antihypertensive therapy may shift with age. In certain cases, reducing or discontinuing antihypertensive treatment (deprescribing) may be appropriate. This systematic review and meta-analysis aimed to summarize available evidence on deprescribing antihypertensive medications in older adults aged 65 years and older.

Methods

We searched MEDLINE, Embase, CINAHL, the Cochrane Library, the Web of Science Core Collection, ClinicalTrials.gov, ICTRP and Epistemonikos from inception to July 2024. We included randomized controlled trials (RCTs) and comparative observational studies (OS) comparing deprescribing versus continuation of antihypertensive medications in adults ≥ 65 year

SUBMITTER: Floriani C 

PROVIDER: S-EPMC12911232 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature