A novel mechanistic insight: BYHWD glycosides promote vascular endothelial repair via EPCs.

ABSTRACT:

Objective

To explore the mechanism of glycosides from BYHWD promote EPCs repairing damaged vascular endothelium.

Methods

A model of vascular intimal damage in rats and an aging model in EPCs were established. HE staining was carried out to examine the blood vessel intima; Elisa assays were employed to assess the levels of TC, TG, HDL-C, LDL-C, Col-1, MMP-9, and TIMP-1; frozen sections were utilized to detect the homing status of EPCs in vivo; western blot was used to detect the contents of eNOS, ITGβ3, ITGβ6, FAK, P-FAK, ERK1/2 and P-ERK1/2; the CCK-8 assay was used to evaluate the proliferation rate; the cell migration test was used to evaluate cell migration capabilities; and the tube formation test was used to determine the tube formation ability.

Results

BYHWD, gl

SUBMITTER: Yan FC 

PROVIDER: S-EPMC12911260 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature