Antimicrobial use in pediatric hematopoietic stem cell transplantation in China: a retrospective multicenter cohort study.

ABSTRACT:

Background

Hematopoietic stem cell transplantation (HSCT) is integral to the management of pediatric hematologic malignancies and non-malignant disease, but infection is a significant cause of morbidity and mortality. The purpose of this study is to assess the application of antimicrobial agents in pediatric HSCT.

Methods

This multicenter retrospective observational cohort study was conducted across 21 hospitals in China. We included pediatric patients who underwent HSCT and received antimicrobial treatment between January 2023 and April 2024. The study collected and analyzed data on patients' disease types, antibiotic use, antifungal drug use, and treatment durations, with subgroup analysis based on age. Statistical analysis was performed using Python 3.13.

Results

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SUBMITTER: Cui Y 

PROVIDER: S-EPMC12911267 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature