Stress hyperglycemia ratio in risk stratification and treatment optimization for patients on invasive mechanical ventilation: a secondary analysis of the MIMIC-IV database.

ABSTRACT:

Background

The association between stress hyperglycemia ratio (SHR), quantifying acute hyperglycemia relative to chronic glycemic status, and outcomes in patients on invasive mechanical ventilation (IMV) remains inadequately explored. This study aimed to evaluate the prognostic value of SHR concerning mortality and its potential to inform treatment decisions for patients undergoing IMV.

Methods

MIMIC-IV database provided analysis data. The endpoints were one-year or intensive care unit all-cause mortality. Survival analysis, Cox regression, restricted cubic splines and subgroup analyses were performed. Propensity score overlap-weighting as sensitivity analysis ensured robustness.

Results

It encompassed 3600 patients, identifying an optimal cutoff for the SHR of 1.37 f

SUBMITTER: Wang K 

PROVIDER: S-EPMC12911284 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature