Domestic water hardness, genetic susceptibility, and risk of symptomatic abdominal aortic aneurysm: a cohort study of UK biobank.

ABSTRACT:

Objective

This study aimed to investigate the relationship between domestic water hardness and risk of symptomatic abdominal aortic aneurysm (AAA) and explore whether this association was modified by genetic predisposition to AAA.

Methods

Exposures of interest included concentration of calcium (Ca), magnesium (Mg), calcium carbonate (CaCO₃) as well as water hardness. Symptomatic AAA was identified through ICD code and operation code. Multivariable Cox proportional-hazard models were used for outcome analysis. Subgroup analysis was performed by the levels of genetic susceptibility to AAA.

Results

This study included 371,668 participants. Over a median follow-up duration of 15.2 years, 2,154 new cases of symptomatic AAA were recorded. A negative association w

SUBMITTER: Li C 

PROVIDER: S-EPMC12911312 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature