COLEC10 and COLEC11 are new serum biomarkers of chronic liver disease.

ABSTRACT:

Background

COLEC10 and COLEC11 are presumed to act as pattern recognition receptors to activate the complement system by binding to MASP1. However, it is not clear whether the serum concentrations of COLEC10, COLEC11 and MASP1 can be diagnostic markers of chronic liver disease (CLD).

Aims

This study aimed to investigate the diagnostic value of serum concentrations of COLEC10, COLEC11 and MASP1 in CLD.

Methods

The study included 17 healthy donors and 128 patients who were diagnosed with chronic liver disease. The serum concentrations of COLEC10, COLEC11 and MASP1 were measured with ELISA kits. The clinical data of the patients were collected and analyzed.

Results

The serum concentrations of COLEC10 and COLEC11 are significantly increased in the patients with CLD

SUBMITTER: Yang T 

PROVIDER: S-EPMC12911374 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature