<i>Akkermansia muciniphila</i> alleviates experimental colitis through FXR-mediated repression of unspliced XBP1.

ABSTRACT: Endoplasmic reticulum (ER) stress-related mucin depletion could be involved in the pathogenesis of ulcerative colitis (UC). Akkermansia muciniphila (A. muciniphila) uses mucin as its sole energy source and shows potential in the treatment of colitis. However, the effects and underlying mechanisms of A. muciniphila on colonic epithelial ER stress in colitis are largely unknown. Colitis was induced by adding 2.5% dextran sulfate sodium (DSS) in drinking water. Mice were orally administered A. muciniphila (3*10^{^}7, 3*10^{^}8 cfu/day) once daily for 10 days during DSS intervention. Ultra high performance liquid chromatography q-exactive orbitrap high-resolution mass spectrometry (UHPLC-Q-Orbitrap-HRMS)-based metabolomic analyses were performed on feces. 1

SUBMITTER: Bu F 

PROVIDER: S-EPMC12911386 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature