Cross-feeding interactions between <i>Fusobacterium nucleatum</i> and the glycan forager <i>Segatella oris</i>.

ABSTRACT: Fusobacterium nucleatum is a common member of the oral microbiota frequently associated with extra-oral infections and diverse polymicrobial environments, including chronic airway diseases and colorectal tumors. Yet, its interactions with co-colonizing microbiota remain poorly defined. Here, we investigate cross-feeding interspecies dynamics between F. nucleatum and Segatella oris, a glycan-foraging anaerobe enriched in the airways, oral cavity, and gastrointestinal tumors. Using broth cultures, cell-free supernatants, and co-culture on primary human airway epithelial cells, we identify microbe-microbe and microbe-host interactions that shape nutrient acquisition, biofilm formation, gene expression, and host responses. While mucin or S. oris supernatants modestl

SUBMITTER: Fletcher JR 

PROVIDER: S-EPMC12911393 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature