Botulinum Toxin Efficacy in Upper Limb Tremor: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Essential tremor (ET) and dystonic tremor syndrome (DTS) can be treated using botulinum toxin (BoNT) injections. Previous reviews lacked an assessment of the certainty of evidence and focused solely on clinician-reported outcomes. Additionally, studies have demonstrated interindividual variability in BoNT efficacy.

Objective

The aim of the study was to assess the efficacy and safety of BoNT injections for ET and DTS of the upper limbs, and to identify factors associated with BoNT efficacy.

Methods

We systematically searched Pubmed, Embase, Cochrane Library, and Web of Science databases for studies on BoNT injections in ET and DTS of the upper limbs. The certainty of evidence was rated using the Grading of Recommendations, Assessment, Development, and Evalua

SUBMITTER: Visser IM 

PROVIDER: S-EPMC12911523 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature