Gut microbiota predict development of postdischarge diabetes mellitus in acute pancreatitis.

ABSTRACT:

Background

Postdischarge morbidity and mortality is high in acute pancreatitis (AP) and pathophysiological mechanisms remain poorly understood.

Objectives

We aim to investigate the composition of gut microbiota and clinical long-term outcomes of prospectively enrolled patients with AP to predict postdischarge complications.

Design

In this long-term follow-up study, we analysed clinical and microbiome data of 277 patients from the prospective multicentre Pancreatitis-Microbiome As Predictor of Severity trial. The primary endpoint was the association of the microbial composition with postdischarge mortality, recurrent AP (RAP), progression to chronic pancreatitis, pancreatic exocrine insufficiency, diabetes mellitus (DM) and pancreatic ductal adenocarcinoma.

Results<

SUBMITTER: Ammer-Herrmenau C 

PROVIDER: S-EPMC12911579 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature