Association between dehydration trajectory, delayed cerebral ischemia, and functional outcome in patients with aneurysmal subarachnoid hemorrhage: assessment of interaction and mediation.

ABSTRACT:

Background

Blood urea/creatinine (U/Cr) ratio is considered to be an ideal biomarker of dehydration. We investigated the association between the U/Cr ratio trajectory and delayed cerebral ischemia (DCI) as well as functional outcome in aneurysmal subarachnoid hemorrhage (aSAH). Additionally, we explored the role of DCI as a mediator and its interaction with dehydration.

Methods

Consecutive aSAH patients were reviewed. A latent class growth mixture model (LCGMM) was applied to classify the dehydration trajectory over 7 days. Multivariate logistic regression was conducted to examine associations between dehydration trajectories, DCI, and poor outcome. Furthermore, causal mediation analysis combined with a four-way decomposition approach was employed to quantify the extent to w

SUBMITTER: Zhang P 

PROVIDER: S-EPMC12911649 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature