Development of the 'COuld it Be RA' (COBRA) tool to facilitate early identification of people at risk of developing rheumatoid arthritis in primary care.

ABSTRACT:

Objectives

We aimed to develop a new complex intervention, the 'COuld it Be RA' (COBRA) tool, to support the implementation of a clinical prediction model to identify people likely to be anti-cyclic citrullinated peptide (CCP) positive and at risk of rheumatoid arthritis in primary care.

Methods

The COBRA tool was developed using the UK Medical Research Council and National Institute for Health and Care Research complex intervention research framework. This study involved three sequential phases with primary care clinicians: a qualitative descriptive study, clinician consultation engagement workshops and a think-aloud interview study. Ethical approval was obtained for all three phases.

Results

Sixteen primary care clinicians participated in semistructured interviews t

SUBMITTER: Siddle HJ 

PROVIDER: S-EPMC12911672 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature