Age and sex differences in diabetic ketoacidosis outcomes in type 1 diabetes: a national cohort study.

ABSTRACT:

Background

Despite therapeutic advances, diabetic ketoacidosis (DKA) hospitalizations continue to increase. The role of demographic factors, including age and sex in the outcomes of DKA remains underexplored. We aimed to investigate the interaction between age and sex on clinical outcomes, resource utilization and mortality in patients with type 1 diabetes hospitalized for DKA.

Methods

We conducted a retrospective cohort study using the National Inpatient Sample from 2016 to 2021. We identified adult hospitalizations with DKA in patients with type 1 diabetes, stratified into three age groups: 18-44, 45-64 and ≥65 years. Multivariable logistic regression models were used to analyze the association between sex and the primary outcome of in-hospital mortality, and secondary out

SUBMITTER: Chia JE 

PROVIDER: S-EPMC12911798 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature