EPCs-derived exosomal miR-7116-3p alleviate high glucose-induced endothelial cell dysfunction by targeting Orai1-IGFBP3 complexes.

ABSTRACT:

Introduction

Diabetic vascular complications are predominantly caused by high glucose (HG)-induced endothelial dysfunction. Exosomes derived from endothelial progenitor cells (EPCs-EXOs) have shown therapeutic potential by modulating cellular functions through the delivery of bioactive cargos, particularly microRNAs (miRNAs). This study examines the role of EPCs-EXOs and their miRNA cargo in mitigating HG-induced endothelial dysfunction by targeting the Orai1-insulin-like growth factor-binding protein 3 (IGFBP3) signaling axis, a critical mediator of store-operated calcium entry (SOCE) and vascular pathology in diabetes.

Research design and methods

Human coronary artery endothelial cells (HCAECs) were cultured under HG (25 mM) or normal glucose (5.6 mM) conditions to model e

SUBMITTER: Han S 

PROVIDER: S-EPMC12911840 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature