Glutathione-activatable synthetic channel for hopping-mediated anion transport.

ABSTRACT: Controlled transport of ions across the cellular membrane is an essential process. While nature employs stimuli-gated transmembrane proteins to facilitate the appropriate transport of essential ions or molecules across cellular membranes, the endeavor to create a stimuli-controlled synthetic analogue presents considerable challenges. Herein, we introduced isophthalamide-based synthetic ion transporters 1a-1e and a protransporter 1c'. Transport studies divulged that even though the protransporter 1c' cannot transport the anions, the glutathione-based activation generates a self-assembled anion channel 1c in the membrane and turns ON the anion transport with preferential selectivity towards the chloride anion. Detailed mechanistic studies validated that the transport of anions occurs via<

SUBMITTER: Chattopadhayay S 

PROVIDER: S-EPMC12911877 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature