Pseudovibriamide B from marine sponge-associated bacteria acts as a selective antibiotic antidote.

ABSTRACT: Broad-spectrum antibiotics, while effective against pathogens, can disrupt microbiota leading to dysbiosis. In natural systems, where most antibiotic classes were first identified, some collateral damage control may have evolved as a microbiota protection strategy to the production of broad-spectrum antibiotics. In this work, we investigated whether pseudovibriamide B (PB), a depsipeptide produced by the marine sponge isolated bacterium Pseudovibrio brasiliensis Ab134, can function as a selective antidote to the commercial broad-spectrum antibiotic blasticidin S. An analogue of blasticidin S, named P10, was previously isolated from marine sponges. To improve access to PB and enable testing of the hypothesis, we developed an overexpression strategy targeting core biosynthetic genes,

SUBMITTER: Lourenzon V 

PROVIDER: S-EPMC12911931 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature