Unraveling Endocannabinoid Signaling Pathways in Cisplatin-Induced Ototoxicity.

ABSTRACT: Cisplatin-induced ototoxicity is a detrimental side effect of chemotherapy leading to hearing loss, for which no treatments are currently available. Despite the growing recognition of the endocannabinoid (eCB) system (ECS) as a significant contributor to different physiological and pathological processes, its role in hearing remains poorly investigated. To fill this knowledge gap, we performed a molecular profiling of the ECS in auditory hair cell (HC)-like UB/OC1 cells derived from the mouse organ of Corti (OC), demonstrating the presence of the main eCBs-binding receptors and metabolic enzymes along with the major eCBs (N-arachidonoylethanolamine, AEA, and 2-arachidonoylglycerol, 2-AG) and additional eCB-like compounds. Subsequently, we established an in vitro model of cisplatin-induced

SUBMITTER: Palaniappan S 

PROVIDER: S-EPMC12911942 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature