Supersonic Cryogenic Jet Delivery of Polynucleotides Compared With Manual Intradermal Injection.

ABSTRACT:

Background

This study explores an alternative method of delivering polynucleotides (PNs) using a transdermal drug delivery device instead of traditional injection methods. These devices can deliver PNs in a noncontact manner and may offer several advantages over traditional injection techniques, including reduced pain and faster recovery time.

Methods

A clinical trial was conducted to compare the effectiveness of PN injections and transdermal drug delivery devices in 4 participants. Each participant received 3 treatments using the injection method on one side of the face and the transdermal drug delivery device on the other. The right hemiface was treated with cryogenic transdermal delivery (TargetCool), and the left hemiface was treated with manual intradermal injection. Ou

SUBMITTER: Kim M 

PROVIDER: S-EPMC12912074 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature