Osteocyte-Intrinsic MMP13 exacerbates injury-induced temporomandibular joint osteoarthritis.

ABSTRACT:

Objective

Cartilage in the knee and temporomandibular joint (TMJ) rely on subchondral bone for joint homeostasis, whereby osteoarthritis (OA) causes degeneration. In the knee, suppression of osteocytic perilacunocanalicular remodeling drives cartilage degeneration in a destabilization of the medial meniscus model of OA. Given the structural and functional differences between knee and TMJ osteochondral tissues, whether osteocytes also play a causal role in TMJOA remains to be determined. We hypothesize that subchondral bone osteocytes are required for TMJ homeostasis.

Method

We evaluated the role of osteocytic MMP13 in the TMJ using 16-week-old mixed FVB and C57BL/6 male mice with osteocyte-intrinsic loss of MMP13 (DMP1-cre^+/-;MMP13^fl/fl). DMP1-cre⁺

SUBMITTER: Yee CS 

PROVIDER: S-EPMC12912257 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature