Thermal plasticity of adrenaline-mediated, frequency-dependent calcium homeostasis in rainbow trout ventricular cardiomyocytes.

ABSTRACT: The effect of global warming on rising aquatic temperatures is producing ever-steeper thermoclines. Fish encountering these sharp changes in water temperature might experience an acute-warming stress. Temperature is the most dominant environmental factor affecting heart function in fish, and without compensatory mechanisms as temperatures rise (e.g. higher heart rate), it could imperil cardiovascular performance. To enhance heart function during acute warming, fish release adrenaline to boost Ca2+ influx in heart cells (cardiomyocytes). However, the relationship between acute warming, elevated heart rate, adrenergic stimulation and intracellular Ca2+ handling is not well understood at the cellular level. In this study, we investigated the interplay between these key functional drivers in i

SUBMITTER: Ruhr IM 

PROVIDER: S-EPMC12912269 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature